** (RuntimeError) ThousandIsland on HTTP load test

You were absolutely right about file descriptors! Simply increasing the hard limit for the number of open descriptors per process completely solves the issue

Running 30s test @ http://127.0.0.1:4000/token
  20 threads and 9900 connections
  Thread Stats   Avg      Stdev     Max   +/- Stdev
    Latency   127.40ms   52.07ms   1.47s    94.65%
    Req/Sec     3.94k   356.81     8.21k    89.22%
  Latency Distribution
     50%  123.67ms
     75%  132.27ms
     90%  142.21ms
     99%  290.75ms
  2331183 requests in 30.10s, 0.94GB read
Requests/sec:  77451.24
Transfer/sec:     32.06MB